A case for exercising

Submitted by gary on
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August 24th, 2010 in Medicine & Health / Research

There is now another good reason to exercise. Besides burning calories, exercise restores the sensitivity of neurons involved in the control of satiety (feeling full), which in turn contributes to reduced food intake and consequently weight loss. This is the conclusion of a study led by Brazilian researchers at the University of Campinas, and the findings will be published next week in the online, open access journal PLoS Biology. This disclosure may bring hope to over 40% of the population that suffers from weight problems and obesity around the world.

The increase in obesity has become one of the most important clinical-epidemiological phenomena. Factors such as changing eating habits and a sedentary lifestyle both have a role in the pathogenesis of this disease. It is postulated that excessive consumption of fat creates failures in the signal transmitted by neurons controlling satiety in a region of the brain called the hypothalamus. These failures can lead to uncontrollable food intake and, consequently, obesity.

The group led by José Barreto C. Carvalheira demonstrated that exercising obese rodents showed signals of restored satiety in hypothalamic neurons and decreased food intake. "In obese animals, exercise increased IL-6 and IL-10 protein levels in the hypothalamus, and these molecules were crucial for increasing the sensitivity of the most important hormones, insulin and leptin, which control appetite," Carvalheira explained. Physical activity contributes to the prevention and treatment of obesity, not only by increasing energy expenditure but also by modulating the signals of satiety and reducing food intake.

Physical activity has always been considered a cornerstone in the treatment of obesity, however, only now have the effects of exercise on the control of body weight been understood. Thus, these findings, besides reinforcing the necessity for regular exercise also change the current paradigm established between physical activity and weight loss.

More information: Ropelle ER, Flores MB, Cintra DE, Rocha GZ, Pauli JR, et al. (2010) IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKb and ER Stress Inhibition.

PLoS Biol 8(8): e1000465. doi:10.1371/journal.pbio.1000465

Provided by Public Library of Science
"A case for exercising." August 24th, 2010. www.physorg.com/news201890168.html


Exercise does both of these

Exercise does both of these for me. I will blog about how I am doing tonight maybe. Just brief I have managed to get my exercise routine going again and I am at day 11 without M or O. Also my diet is about 90% back on track. Also I have just about got my supplements sorted. A couple I think are cause some very good reactions I will talk about in my blog.


I believe that as human beings we are designed to and meant to exercise, it's in our genes.
Not that long ago, in the grand scheme of things, we would be spending hours each day hunting/gathering food and expending energy on survival. Our world has evolved faster than we can keep up - we arent meant to be sitting down for hours each day and eating the food we do. Maybe we will catch up one day!

Well said

Often it's useful to consider what our equipment was designed to cope with, as our balance is calibrated for those conditions.

Even though conditions have changed rapidly of late, we can actually meet a lot of those subtle needs simply by becoming aware of them: exercise, companionship, rare...but not continual...binges, and reflection, among others.